Hepatocyte growth factor—a culprit of drug resistance
نویسندگان
چکیده
منابع مشابه
Drug Resistance
عفونت و تهاجم ارگانیسم های انگلی به بدن، عامل اصلی بیماری و مرگ انسانها از آغاز بشریت بوده است . در حقیقت بسیاری از اشکال حیات بدون غلبه بر ارگانیسم های زنده دیگر، قادر به ادامه زندگی نخواهند بود. انسانها معمولا مستعد تهاجم ارگانیسم های کوچکتری مانند کرمها، آمیب ها، قارچها، باکتریها و ویروسها هستند. این عوامل مکان خاصی را در بدن انتخاب کرده، مواد ضروری لازم برای حیات و تکثیر خود را دریافت نموده...
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Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. However, 25% to 30% of patients with EGFR-activating mutations show intrinsic resistance, and the responders invariably acquire resistance to gefitinib. Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, i...
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INTRODUCTION Epidermal growth factor receptor (EGFR) is an attractive drug target in lung cancer, with several anti-EGFR antibodies and small-molecule inhibitors showing efficacy in lung cancer patients. Patients, however, may develop resistance to EGFR inhibitors. We demonstrated previously that hepatocyte growth factor (HGF) induced resistance to EGFR tyrosine kinase inhibitors in lung cancer...
متن کاملHepatocyte Growth Factor
Hepatocyte growth factor (HGF) exerts biological activity through the Met receptor tyrosine kinase. HGF plays essential roles in the embryonic development of the liver and placenta, and in the migration of myogenic precursor cells. In mature tissues, HGF plays roles in tissue protection and regeneration, including in the liver and kidney. HGF participates in invasion, metastasis, and drug resis...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2012
ISSN: 1759-4774,1759-4782
DOI: 10.1038/nrclinonc.2012.124